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Physikalische Kartierung eines Blutdruck-assozi...
58,00 € *
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Inhaltsangabe:Zusammenfassung: Bluthochdruck, ein wichtiger Risikofaktor für Herz-Kreislauferkrankungen, betrifft etwa 15-20% der Bevölkerung in westlichen Industrienationen. Abgesehen von seltenen monogenetischen Formen wird er in über 90% der Fälle durch die Wechselwirkung von mehreren, bisher weitgehend unbekannten Genen untereinander und mit Umweltfaktoren ausgelöst. Ein mit Bluthochdruck assoziierter QTL (quantitative trait locus) wurde in der Ratte auf Chromosom 10 gefunden und BP/SP1 bezeichnet (blood pressure/stroke prone). Diese Region ist evolutionär offenbar stark konserviert und findet sich auch beim Menschen auf Chromosom 17, wo ebenfalls eine Assoziation mit Bluthochdruck nachgewiesen wurde. Durch die Etablierung von congenen Linien konnte BP/SP1 in zwei kleinere QTLs, BP/SP1a und BP/SP1b, unterteilt werden, von denen durch IRS-PCR walking (interspersed repetitive sequence) YAC -Klon Contigs bereits konstruiert wurden. In der vorliegenden Diplomarbeit wurde eine Feinkartierung beider QTLs durch PAC-Klone durchgeführt, d.h. es sollten korrespondierende PACs zu den YAC-Klonen der BP/SP1a und b Contigs gefunden werden. Dazu wurden 37 YAC-Klone aus den BP/SP1a und b Contigs gegen jeweils zwei Hochdichtefilter der PAC-Bibliothek Rat PAC mit 27648 Klonen pro Filter hybridisiert, was etwa zwei Genomäquivalenten pro YAC entspricht. 251 PACs konnten so identifiziert werden. Bei einer anschließenden IRS-PCR lieferten 37,1% der Klone (93 PACs) IRS-PCR-Produkte, die zur Radiation-Hybrid (RH)-Kartierung sowie zur Kartierung über korrespondierende YACs herangezogen wurden. 50 PAC-Klone konnten durch RH-Mapping kartiert werden, davon 33 Klone auf Chromosom 10. Die anderen 17 verteilen sich auf die Chromosomen 1, 6, 7, 11, 12, 13, 15 und 20. Für 66 PACs konnten durch Hybridisierung gegen YAC-Pool-Filter der beiden Bibliotheken Rat YAC und WI/MIT Rat YAC mit zusammen 20 Genomäquivalenten korrespondierende YACs bestimmt werden, wobei pro Filter zwischen 2 und 15 YACs getroffen wurden. 17 dieser 66 PACs konnten zusätzlich auch RH-kartiert werden. Inhaltsverzeichnis:Inhaltsverzeichnis: Zusammenfassung7 Abkürzungsverzeichnis8 1Einleitung9 1.1Projektschema der Diplomarbeit9 1.2Bluthochdruck10 1.3Die Ratte als Tiermodell für die Erforschung komplexer genetischer Erkrankungen11 1.4Die Identifizierung von Genen14 1.4.1Kartierung des BP/SP1 Intervalls14 1.4.2Congene Rattenlinien16 1.5Die positionelle Klonierung (Positional [...]

Anbieter: Thalia AT
Stand: 03.12.2020
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Ecco  Sneaker Schnuerschuhe Outdoor Biom Yac 83...
139,95 € *
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Ecco Sneaker Schnuerschuhe Outdoor Biom Yac 837533/01422 Rose In Damengrößen erhältlich. 40. Jetzt Schnuerschuhe Outdoor Biom Yac 837533/01422 von Ecco auf Spartoo.de versandkostenfrei bestellen! 5% Rabatt mit Code: AH56

Anbieter: Spartoo
Stand: 03.12.2020
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A   Guide to the Rules of Yacht Racing - A Coll...
57,90 CHF *
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This book contains classic material dating back to the 1900s and before. The content has been carefully selected for its interest and relevance to a modern audience.

Anbieter: Orell Fuessli CH
Stand: 03.12.2020
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POLA - B.A Grandluxe II Facial Serum 50g/1.7oz
840,70 € *
zzgl. 22,25 € Versand

Brand from Japan: POLA. Original beauty ingredients such as newly developed cellence AC, YAC extract, sugina extract, ursolic acid derivatives and so on, and the brightening active ingredient lucinol R. are luxuriously blended. Ingredients, which POLA is proud of, are gathered in this milky serum. A special serum which was born under the new anti-aging idea that takes the aging positively and turns it to the sparkling power. A rich, extravagant drop of the serum milk, focusing on ingredients, texture, and scent, leads to the gorgeous skin filled with shiny aura. The scent of luxury garden with images of flowers such as jasmine and rose. How to use: Use after lotion. Dispense 1-2 pumps or an appropriate amount according to skin conditions and smooth over entire face.

Anbieter: YesStyle
Stand: 03.12.2020
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Positional Cloning by Exon Trapping and cDNA Se...
239,00 CHF *
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Tremendous strides in decoding the human genome have been made over the last ten years. Large, chromosome-scale, genome-scale EST-sequencing and mapping techniques have dramatically expanded the base of identified genes and sequenced DNA. Gene isolation and cloning techniques that emerged earlier on, however, still remain effective mainstays for constructing dense transcript maps to isolate coding sequences and disease-associated genes contained within a specific chromosomal region. Positional Cloning by Exon Trapping and cDNA Selection examines two powerful methods for locating the coding region of a given gene by isolating gene fragments from individual clones or pools of genomic clones. This comprehensive guide details the exon-trapping and cDNA selection processes step by step-from isolating genomic templates and nuclear splicing, to verifying generated clones and sequenced data, to analyzing exon libraries and cDNA sublibraries. Procedures covered include: * Exon-trapping systems and descriptions of pSPL1 and pSPL3 vectors. * Exon amplification protocols for preparing vectors for cloning; subcloning genomic DNA into vectors; transformation, analysis, and transfection of sublibraries; RNA transcription; and PCR amplification and PCR product cloning. * Evaluation of exon libraries by PCR colony testing, identifying artifactual clones using Southern blot, and sequencing and mapping back candidate exons. * Isolation of genomic templates, such as COSMID-, P1-, PAC, and YAC DNA. * cDNA selection experiment protocols including cDNA screening, hybridization, and biotinylation; preparation of genomic and cDNA sources; and PCR cloning. * Clone analysis and analysis by hybridization. Positional Cloning by Exon Trapping and cDNA Selection offers researchers, scientists, and graduate students an invaluable tool for probing gene distribution and molecular organization. Most importantly, it provides a critical approach to isolating specific disease genes within a targeted genomic area.

Anbieter: Orell Fuessli CH
Stand: 03.12.2020
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Yeast Artificial Chromosome
39,00 € *
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High Quality Content by WIKIPEDIA articles! A yeast artificial chromosome (short YAC) is a vector used to clone large DNA fragments (larger than 100 kb and up to 3000 kb). It is an artificially constructed chromosome and contains the telomeric, centromeric, and replication origin sequences needed for replication and preservation in yeast cells. Built using an initial circular plasmid, they are linearised by using restriction enzymes, and then DNA ligase can add a sequence or gene of interest within the linear molecule by the use of cohesive ends. They were first described in 1983 by Murray and Szostak. Yeast expression vectors, such as YACs, YIps (yeast integrating plasmid), and YEps (yeast episomal plasmid), are extremely useful as one can get eukaryotic protein products with posttranslational modifications as yeasts are themselves eukaryotic cells, however YACs have been found to be more unstable than BACs, producing chimeric effects. Before the advent of the Human Genome Project, YACs and BACs were used to map sections of DNA of interest when hunting for specific genes.

Anbieter: Dodax
Stand: 03.12.2020
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Portable Bluetooth Speakers Philips Tas6305/00 ...
110,38 € *
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If you're passionate about IT and electronics, like being up to date on technology and don't miss even the slightest details, buyPortable Bluetooth Speakers Philips TAS6305/00 20W Black at an unbeatable price.Waterproof and ready to goThis portable Bluetooth speaker is IPX7-rated—which means it can withstand total immersion in water up to 1 m deep for up to 30 minutes. You can party in the shower, by the pool or even in the pool! The wireless range is 20 m.20 hours of play time. Built-in power-bank functionThe 4400 mAH rechargeable Li-ion battery gives you 20 hours of play time and you can charge your smart device via the speaker's USB port. A full charge of the battery takes 6 hours.Play it loud. Pair for stereoTwin passive radiators deliver strong bass and sound stays clear even at high volume. Want to make the party even bigger? Pair with an identical speaker for stereo sound. LED lights at each end of the speaker flash in time with the tunes.Audio-in. Connect to almost any sourceWant to connect to an external audio source like a turntable or MP3 player? The audio-in socket at the back of the speaker lets you connect to almost any electronic device.Anti-clipping function. Play it loud without distortionAnti-Clipping lets you play music louder and keeps its high quality, even when the battery is low. It accepts a range of input signals, from 300 mV to 1000 mV and keeps your speakers safe from damage by distortion. This built-in function monitors the musical signal as it goes through the amplifier and keeps peaks within the amplifier's range, preventing the audio distortion caused by clipping without affecting loudness. A portable speaker's ability to reproduce musical peaks decreases along with battery power, yet anti-clipping reduces peaks caused by low battery, keeping music distortion-free.Multi-colour LED lights blaze to the beatWhen the party's pumping, so is the light show. LED lights at each end of the speaker flash to the tunes.Pair with an identical speaker for stereo soundConnecting to your Bluetooth device is simple. One short press on the Bluetooth button and the speaker is ready to pair.Two passive radiators for strong bassTwin passive radiators deliver strong bass and sound stays clear even at high volume. Want to make the party even bigger? Pair with an identical speaker for stereo sound. LED lights at each end of the speaker flash in time with the tunes.Waterproof and ready to goThis portable Bluetooth speaker is IPX7-rated—which means it can withstand total immersion in water up to 1 m deep for up to 30 minutes. You can party in the shower, by the pool or even in the pool! The wireless range is 20 m.20 hours of play time. Built-in power-bank functionThe 4400 mAH rechargeable Li-ion battery gives you 20 hours of play time and you can charge your smart device via the speaker's USB port. A full charge of the battery takes 6 hours.Play it loud. Pair for stereoTwin passive radiators deliver strong bass and sound stays clear even at high volume. Want to make the party even bigger? Pair with an identical speaker for stereo sound. LED lights at each end of the speaker flash in time with the tunes.Audio-in. Connect to almost any sourceWant to connect to an external audio source like a turntable or MP3 player? The audio-in socket at the back of the speaker lets you connect to almost any electronic device.Anti-clipping function. Play it loud without distortionAnti-Clipping lets you play music louder and keeps its high quality, even when the battery is low. It accepts a range of input signals, from 300 mV to 1000 mV and keeps your speakers safe from damage by distortion. This built-in function monitors the musical signal as it goes through the amplifier and keeps peaks within the amplifier's range, preventing the audio distortion caused by clipping without affecting loudness. A portable speaker's ability to reproduce musical peaks decreases along with battery power, yet anti-clipping reduces peaks caused by low battery, keeping music distortion-free.Multi-colour LED lights blaze to the beatWhen the party's pumping, so is the light show. LED lights at each end of the speaker flash to the tunes.Pair with an identical speaker for stereo soundConnecting to your Bluetooth device is simple. One short press on the Bluetooth button and the speaker is ready to pair.Two passive radiators for strong bassTwin passive radiators deliver strong bass and sound stays clear even at high volume. Want to make the party even bigger? Pair with an identical speaker for stereo sound. LED lights at each end of the speaker flash in time with the tunes.Number of speakers: 2Number of passive radiators: 2Speaker type: 2.5-wayRMS rated power: 20 WSpeakers RMS power: 10 WConnectivity technology: WirelessWi-Fi: NBluetooth: Y3.5 mm connector: YBluetooth version: 5.0Bluetooth profiles: A2DP,AVRCP,HFP,HSPBluetooth range: 20 mUSB connectivity: YDC-in jack: YProduct colour: BlackVolume control: DigitalOn/off switch: YInternational Protection (IP) code: IPX7LED indicators: PowerRecommended usage: Mobile phone / SmartphoneEasy pairing: YMobile operating systems supported: Android 2.1,Android 2.2,Android 2.3,Android 3.0,Android 3.1,Android 3.2,Android 4.0,Android 4.1,Android 4.2,Android 4.2.1,Android 4.2.2,Android 4.3,Android 4.4,Android 5.0,Android 5.1,Android 6.0,Android 7.0,Android 7.1,Android 7.1.2,Android 8.0,Android 9.0,BMP 1.0.4Power source type: Battery,USBBattery type: Built-in batteryBattery technology: Lithium-Ion (Li-Ion)Battery capacity: 4400 mAhBattery voltage: 7.4 VBattery life (max): 20 hBattery recharge time: 6 hBuilt-in charger: YAC adapter output voltage: 5 VWidth: 230 mmDepth: 100 mmHeight: 100 mmWeight: 800 gPackage width: 288 mmPackage depth: 130 mmPackage height: 130 mmPackage weight: 1 kgQuantity per pack: 1 pc(s)Cables included: USBQuick start guide: YWarranty card: YPackage type: Box

Anbieter: G2A
Stand: 03.12.2020
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Analyse des Web-Frameworks Ruby on Rails anhand...
4,99 € *
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Die Analyse des Web-Frameworks Ruby on Rails (Rails), ist eines von fünf Arbeitsthemen des Spezialisierungsthemengebietes 'Web-Engineering' der Fachhochschule Technikum Wien. Die Ausarbeitung basiert auf der Beispielanwendung Yet Annother Community (YAC). Diese Applikation wurde von den fünf Studenten des Spezialisierungsthemengebietes 'Web-Engineering' ausgewählt und zwei exemplarische Use Cases wurden implementiert. Beide Use Cases wurden vollständig vertikal implementiert, um herauszufinden wie Rails den agilen Entwicklungsprozess und das Rapid Application Development unterstützt. Die Vorbereitungsarbeiten (Aufbau der Datenbank, generieren des Rails-Projektes, Scaffolding, Objektrelationales Mapping) für die Implementierung der beiden Use Cases hat gezeigt, dass Rails ein sehr stabiles und zuverlässiges Web-Framework ist und den Programmierer effizient bei der Entwicklung von Webapplikationen mit agilen Prozessen unterstützt. Alle Hauptanforderungen und die beiden Use Cases 'Registrieren eines Users' und 'Login eines Members' wurden mit den Rails Generatoren 'Action Mailer', 'Login_generator', 'Scaffold Generator' und Modifikationen in den Controllern und Views implementiert. Diese Generatoren bauen eine sehr klare MVC-Struktur auf und erleichtern dadurch die Anpassung der Web-Applikation. Das konsequente Verfolgen und Umsetzen der MVC Architektur in Verbindung mit den Active Records und den Prinzipien DRY und 'Konventionenen statt Konfigurationen' machen Rails zu einem sehr agilen Web-Framework und daher auch zu einem perfekten Tool für Rapid Application Development.

Anbieter: Thalia AT
Stand: 03.12.2020
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Ecco  Sneaker Schnuerschuhe Outdoor Biom Yac 83...
139,95 € *
ggf. zzgl. Versand

Ecco Sneaker Schnuerschuhe Outdoor Biom Yac 837533/01422 Rose In Damengrößen erhältlich. 38. Jetzt Schnuerschuhe Outdoor Biom Yac 837533/01422 von Ecco auf Spartoo.de versandkostenfrei bestellen! 5% Rabatt mit Code: 5BLACKWEEK

Anbieter: Spartoo
Stand: 03.12.2020
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Ecco  Sneaker Schnuerschuhe Outdoor Biom Yac 83...
139,95 € *
ggf. zzgl. Versand

Ecco Sneaker Schnuerschuhe Outdoor Biom Yac 837533/01422 Rose In Damengrößen erhältlich. 41. Jetzt Schnuerschuhe Outdoor Biom Yac 837533/01422 von Ecco auf Spartoo.de versandkostenfrei bestellen!

Anbieter: Spartoo
Stand: 03.12.2020
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YAC Protocols
112,49 € *
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YAC Protocols ab 112.49 € als gebundene Ausgabe: Auflage 2006. Aus dem Bereich: Bücher, Wissenschaft, Biologie,

Anbieter: hugendubel
Stand: 03.12.2020
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Ecco  Sneaker Schnuerschuhe Outdoor Biom Yac 83...
139,95 € *
ggf. zzgl. Versand

Ecco Sneaker Schnuerschuhe Outdoor Biom Yac 837533/01422 Rose In Damengrößen erhältlich. 38. Jetzt Schnuerschuhe Outdoor Biom Yac 837533/01422 von Ecco auf Spartoo.de versandkostenfrei bestellen! 5% Rabatt mit Code: AH56

Anbieter: Spartoo
Stand: 03.12.2020
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